Amakuru - Umwicanyi wihishe mu Isi y'Imbwa Ubwinshi bw'Ingufu Zikabije

Ba nyir'amatungo bashobora kuba barumvise iby'indwara y'ubushyuhe bw'imbwa—indwara yica ikwirakwira mu muryango ikunze kubaho mu buryo butunguranye nyuma yo gusinziriza. Mu by'ukuri, ifitanye isano rya bugufi n'ibintu bidasanzwe mu mubiriRYR1 gene, nagupima aside y'ingirabuzimafatizoni ingenzi mu kumenya iki kibazo cya genetiki mbere y'igihe.

Ku bijyanye n'imiterere y'umurage wayo, abahanga mu bya siyansi bemeranya ko ikurikizaumurage ugengwa na autosomal hamwe no kwinjira mu buryo butuzuye—bivuze ko imbwa zirimo gene yahinduwe zishobora kutagaragaza ibimenyetso buri gihe; uko bigaragara biterwa n'ibintu biyitera ndetse n'urugero rw'imyitwarire y'ingirabuzimafatizo.

Uyu munsi, reka turebere hamwe uburyo iyi ndwara ibaho muri ubu buryo bw’uturemangingo n’impamvu zishobora kuyitera.

Ibanga riri inyuma ya RYR1 Gene rigiye kuva mu igenzura

Kugira ngo dusobanukirwe imikorere y’ubwonko bw’imbwa butera kanseri, tugomba kubanza kumenya "akazi ka buri munsi" ka gene ya RYR1—ikora nk'"umurinzi w'imiyoboro ya kalisiyumu"mu turemangingo tw'imitsi. Mu bihe bisanzwe, iyo imbwa yimuka cyangwa ikeneye gufunga imitsi, umuyoboro ugenzurwa na gene ya RYR1 urafunguka, urekura iyoni za kalisiyumu zabitswe mu mitsi kugira ngo itangire gufunga. Nyuma yo gufunga, umuyoboro urafunga, kalisiyumu isubira mu bubiko, imitsi iraruhuka, maze

inzira yose ikomeza kuba nziza kandi ikagenzurwa, nta bushyuhe bwinshi bukabije butanga.

Ariko, iyo gene ya RYR1 ihindutse (kandi autosomal dominant inheritance bivuze ko kopi imwe yahinduwe ishobora gutera indwara), uyu "mulier" atakaza ubushobozi bwo kuyigenzura. Iba ikigoryi cyane kandi ikunda kuguma ifunguye bitewe n'ibintu bimwe na bimwe, bigatuma iyoni nyinshi za kalisiyumu zinjira mu mitsi mu buryo budasubirwaho.

Muri iki gihe, uturemangingo tw’imitsi tugera mu mimerere ya “gushyuha cyane"Nubwo nta kimenyetso cyo gufunga, zikomeza gukora akazi ko gufunga no gukora imikorere y'umubiri ku buryo budafite akamaro. Ibi bitwara imbaraga vuba kandi bigasohora ubushyuhe bwinshi. Kubera ko imbwa zifite ubushobozi buke bwo gufunga ubushyuhe, iyo ubushyuhe burenze kure gufunga, ubushyuhe bw'umubiri bushobora kwiyongera mu minota mike (kuva kuri 38–39°C kugeza kuri 41°C). Uku gusohora ubushyuhe bwinshi ni cyo kimenyetso cya kanseri itera kanseri. Ikibabaje kurushaho, ni uko kudahuza kwa calcium bikomeza gutera ibibazo byinshi: gufunga imitsi cyane bitanga aside lactic na creatine kinase nyinshi, zikirunda mu maraso zikangiza ingingo nk'impyiko (creatine kinase ishobora kuziba imiyoboro y'impyiko) n'umwijima. Imitsi ishobora gucika iyo ikomeje gufunga, bigatera rhabdomyolysis, bigatera gukomera, ububabare, n'inkari zitukura nk'icyayi (myoglobinuria). Indwara zikomeye zishobora gutera arrhythmia, hypotension, guhumeka vuba, no kunanirwa kw'ingingo nyinshi - hatabayeho ubufasha bwihutirwa, igipimo cy'urupfu kiba kiri hejuru cyane.

Aha tugomba gushimangira ko imbwa zimwe na zimwe zigenda zikora mu buryo butuzuye: zimwe mu mbwa zifite RYR1 mutations ariko ntizigaragaze ibimenyetso mu buzima bwa buri munsi kuko imiterere y’uturemangingo isaba imbarutso. Iyo habayeho ibintu runaka, iyo mutation iba ikora kandi inzira za calcium zigacika intege. Ibi bisobanura impamvu abantu benshi bakomeza kubaho neza mu buzima bwabo bwose iyo batahuye n’ibintu bitera indwara—nyamara bashobora guhura n’ingaruka zitunguranye iyo bahuye n’indwara.

Ibintu bitatu by'ingenzi bitera indwara ya hyperthermie y'imbwa

Inzira z'uruhererekane zavuzwe haruguru zikunze guterwa n'ibyiciro bitatu by'ibintu:

1. Imiti yihariye yo kugabanya ububabare (Iterambere ry'ibanze)Impamvu ikomeye cyane ni imiti imwe n'imwe igabanya ububabare—nk'imitihalothane, isoflurane, sevoflurane, hamwe n'imiti igabanya polarike y'imitsi nka succinylcholine. Iyi miti ikorana neza na gene ya RYR1 yahinduwe, irushaho guhungabanya imiyoboro ya kalisiyumu. Amakuru y'ubuvuzi agaragaza ko hafi 70% by'indwara za kanseri y'imbwa zibaho mu gihe cyo kubagwa hakoreshejwe iyi miti igabanya ububabare, akenshi mu minota 10-30 nyuma yo kuyikoresha. Kudakora neza kw'imbwa nabyo biragaragara hano: zimwe mu mbwa zitwara imiterere y'umubiri zishobora kudakora iyo miti bitewe n'itandukaniro mu mikorere y'uturemangingo cyangwa ubushobozi bwa metabolism.

2. Ubushyuhe bushingiye ku bidukikije n'ibikorwa by'umubiriAhantu hashyushye cyane n'ubushuhe bwinshi (urugero: imodoka zifunze neza, balkoni zitwikiriwe n'izuba) bigabanya ubushyuhe bukabije. Iyo imbwa ikoze ibikorwa bikomeye muri ubwo buryo, ubushyuhe bw'imikorere y'umubiri bwiyongera cyane. Bivanze n'ibidasanzwe bya RYR1, ibi bishobora gutuma gene yahindutse. Hari kandi n'abarwayi bagaragaye mu gihe cyo gutwara bitewe n'ubushyuhe, stress, no kugenda buhoro.

3. Guhangana n'ihungabana rikomeyeGukomereka mu kubagwa, ubwoba butunguranye (urugero, kwirukanwa n'inyamaswa nini, ibisasu by'umuriro bikabije), cyangwa ububabare bukabije (gucika intege, gukomereka) bishobora gutera kwiyongera kwa adrenaline n'indi misemburo itera stress. Iyi misemburo ikora mu buryo butaziguye gene ya RYR1 yahinduwe, igatera irekurwa ridasanzwe rya calcium. Labrador ifite iyi hinduka yigeze kugira ikibazo cyo kutagira umuriro mwinshi bitewe n'stress yatewe n'impanuka y'imodoka—urugero rw'uko umuntu adashoboye kwinjira neza bitewe n'ibintu byo hanze.

Ni ngombwa kumenya ko ubushobozi bwo kwandura butandukana bitewe n'ubwoko bw'inyamaswa.Inyoni zo mu bwoko bwa Labrador Retrievers, Inyoni zo mu bwoko bwa Golden Retrievers, Inyoni zo mu bwoko bwa Beagles, Inyoni zo mu bwoko bwa Vizslas, kandi andi moko afite igipimo cyo hejuru cy’impinduka za RYR1, mu gihe amoko mato nka Chihuahuas na Pomeranians afite abanduye bake bagaragaye. Imyaka nayo igira uruhare—imbwa nto (imyaka 1-3) zigira imikorere ikomeye y’imitsi, bigatuma zibasirwa cyane n’ibintu bizitera indwara kurusha imbwa zikuze.

Gupima imiterere y'uturemangingo: Kwirinda mbere yuko ibimenyetso bigaragara

Ku batunze amatungo, gusobanukirwa izi nzira n'ibindi bituma habaho uburyo bwiza bwo kuyarinda:

Niba imbwa yawe ari iyaubwoko bw'inyamaswa bushobora gutera ibyago byinshicyangwa afiteamateka y'umuryango(gukura mu muryango bivuze ko bene wabo bashobora kugira ihinduka rimwe), buri gihe menyesha abaganga b'amatungo mbere yo gutera ikinya. Bashobora guhitamo imiti itizewe (urugero: propofol, diazepam) no gutegura ibikoresho byo gukonjesha (udupfunyika tw'urubura, ibirahuri byo gukonjesha) n'imiti yihutirwa.

Irindeimyitozo ngororamubiri ikomeyemu gihe cy'ubushyuhe bwinshi.

Gabanyaibihe byo guhangayika cyanekugira ngo bigabanye ingaruka z'ibintu bitera.

Agaciro k'igeragezwa rya aside nucleiqueKu mbwa ifite ikibazo cyo kubura umuriro mwinshi mu mubiri, ni ukumenya niba imbwa yawe ifite RYR1 mutation. Bitandukanye no gupima virusi, aho bipima ubwandu, ubu bwoko bw'ibizamini bugaragaza ibyago byo mu ngirabuzimafatizo. Nubwo imbwa yaba idafite ibimenyetso bitewe no kwinjira mu mubiri mu buryo butuzuye, kumenya imiterere yayo mu ngirabuzimafatizo bituma ba nyirayo bahindura ubuvuzi n'ibyemezo by'ubuvuzi kugira ngo birinde icyayitera—kugira ngo amatungo agire umutekano muri iki kibazo gishobora gushyira ubuzima mu kaga.

Igihe cyo kohereza: Ugushyingo-13-2025