Amakuru - Umwicanyi Wihishe muri Canine WorldMalignant Hyperthermia

Ba nyir'inyamanswa bashobora kuba barumvise hyperthermia ya canine malignant-indwara yica abantu bakunze kubaho gitunguranye nyuma yo gutera anesteya. Nibyingenzi, bifitanye isano rya hafi nibidasanzwe muriRYR1 gene, nagupima aside nucleicni urufunguzo rwo kumenya iyi ngaruka ya genetike hakiri kare.

Kubireba imiterere yumurage, ubwumvikane bwa siyansi nuko bukurikiraautosomal yiganje umurage hamwe na penetrance ituzuye- bisobanura imbwa zitwara gene yahinduwe ntishobora kwerekana ibimenyetso; kwigaragaza biterwa na trigger zo hanze hamwe nurwego rwo kwerekana imiterere.

Uyu munsi, reka twibire cyane muburyo iyi ndwara ibaho muri ubu buryo bwa genetike nibishobora kubitera.

Amayobera Inyuma ya RYR1 Gene Kuva hanze

Kugira ngo dusobanukirwe nuburyo bwa hyperthermia ya canine malignant, dukeneye kubanza kumenya "akazi k'umunsi" gene RYR1 - ikora nka "irembo ry'imiyoboro ya calcium.

inzira yose iguma kuri gahunda kandi igenzurwa, idatanga ubushyuhe bukabije.

Ariko, mugihe gene RYR1 ihindagurika (kandi umurage wiganjemo autosomal bivuze ko kopi imwe ihinduwe ishobora gutera indwara), uyu "murinzi" atakaza ubuyobozi. Ihinduka cyane kandi ikunda guhora ifunguye munsi yikangura, bigatuma ioni nyinshi za calcium zuzura bidasubirwaho mumitsi yimitsi.

Kuri ubu, ingirangingo z'imitsi zigwa mu buryo bwa “gukabya”-N'ubwo nta kimenyetso cyo gusezerana, bakomeza kwishora mu kugabanya ubusa no guhinduranya metabolisme. Ibi bitwara ingufu vuba kandi bikarekura ubushyuhe bwinshi. Kubera ko imbwa zifite ubushobozi buke bwo gukwirakwiza ubushyuhe, iyo umusaruro w’ubushyuhe urenze kure cyane, ubushyuhe bw’umubiri bushobora kwiyongera mu minota mike (kuva kuri 38-39 ° C kugeza kuri 41 ° C). imitsi ikabije itanga aside nyinshi ya lactique na creatine kinase, ikusanyiriza mumaraso kandi ikangiza ingingo nkimpyiko (creatine kinase irashobora gufunga imitsi yimpyiko) numwijima umwijima urashobora guturika mugihe gikabije, bigatuma rhabdomyolysis itera guhumeka, myoglobinuria kunanirwa kwingingo nyinshi-hatabayeho gutabarwa byihutirwa, umubare wimpfu ni mwinshi cyane.

Hano tugomba gushimangira penetrance ituzuye: imbwa zimwe zitwara ihinduka rya RYR1 nyamara ntagaragaza ibimenyetso mubuzima bwa buri munsi kuko imvugo ya gene isaba imbarutso. Gusa iyo hari ibintu bimwe na bimwe bibaye, ihinduka ryimikorere kandi imiyoboro ya calcium ikavaho. Ibi birasobanura impamvu abatwara ibintu benshi bagumana ubuzima bwiza niba batigeze bahura nibitera - nyamara barashobora gutangira gutungurwa iyo bimaze guterwa.

Ibintu bitatu byingenzi bya Canine Malignant Hyperthermi

Urunigi rwasobanuwe haruguru rusanzwe ruterwa nibyiciro bitatu:

1. Ibikoresho byihariye bya Anesthetic (Trigger primaire)Imbarutso ikomeye ikubiyemo imiti imwe n'imwe yo kubabaza - nkahalothane, isoflurane, sevoflurane, hamwe na depolarizing imitsi iruhura nka succinylcholine. Iyi miti ikorana na gene ya RYR1 ihindagurika, bikomeza guhungabanya imiyoboro ya calcium. Amavuriro yerekana ko hafi 70% yindwara ya hyperthermia ya kineine iba mugihe cyo kubagwa ukoresheje anesthetike, akenshi muminota 10-30 nyuma yo kwinjizwa. Kwinjira kwuzuye kutagaragarira kandi hano: imbwa zimwe na zimwe zitwara mutation ntizishobora kwitabira iyi miti kubera itandukaniro ryimiterere ya gene cyangwa ubushobozi bwa metabolike.

2. Ubushyuhe bwibidukikije nibikorwa byumubiriUbushyuhe bwinshi nubushuhe bwibidukikije (urugero, imodoka zishyushye zifunze, balkoni zuba zuba) bigabanya ubushyuhe. Niba imbwa ikora ibikorwa bikomeye mubihe nkibi, ubushyuhe bwa metabolike bwiyongera cyane. Ufatanije na RYR1 idasanzwe, ibi birashobora gukora gene ihindagurika. Imanza nazo zagaragaye mu gihe cyo gutwara abantu kubera ubushyuhe, guhangayika, no kugenda byoroheje.

3. Igisubizo gikomeyeIhahamuka ryo kubaga, ubwoba butunguranye (urugero, kwirukanwa ninyamaswa nini, gucana umuriro mwinshi), cyangwa ububabare bukabije (kuvunika, gukomeretsa) birashobora gutera kwiyongera kwa adrenaline nindi misemburo ya stress. Iyi misemburo ikora mu buryo butaziguye gene ya RYR1 ihindagurika, itera calcium idasanzwe. Labrador itwara mutation yigeze kurwara hyperthermie mbi kubera guhangayikishwa nimpanuka yimodoka - urugero rwo kwinjira kutuzuye guterwa no guterwa hanze.

Ni ngombwa kumenya ko kwandura bitandukana kumoko.Kugarura Labrador, Kugarura Zahabu, Beagles, Vizslas, hamwe nandi moko afite igipimo cyinshi cya RYR1 ihinduka, mugihe amoko mato nka Chihuahuas na Pomeriya afite ibibazo bike byavuzwe. Imyaka nayo igira uruhare-imbwa zikiri nto (1-3 ans) zifite metabolisme ikora cyane, bigatuma zishobora kwibasirwa nimbwa zishaje.

Kwipimisha genetike: Kwirinda mbere yuko Ibimenyetso Bigaragara

Kubafite amatungo, gusobanukirwa nuburyo bukurura bituma habaho gukumira neza:

Niba imbwa yawe ari iya aubwoko bwinshicyangwa ifite aamateka yumuryango(umurage wiganje bivuze ko bene wabo bashobora gutwara mutation imwe), burigihe bimenyesha abaveterineri mbere ya anesthesia. Bashobora guhitamo imiti itekanye (urugero, propofol, diazepam) bagategura ibikoresho byo gukonjesha (paki yubukonje, ibiringiti bikonjesha) hamwe nubuvuzi bwihutirwa.

Irindeimyitozo ikomeyemu gihe cy'ubushyuhe.

Mugabanyeibihe byinshikugabanya imbarutso.

Agaciro ko gupima aside nucleickuri canine malignant hyperthermia iri mukumenya niba imbwa yawe itwara RYR1 mutation. Bitandukanye no gupima virusi, yerekana kwandura, ubu bwoko bwikizamini bugaragaza ingaruka zishingiye ku ngirabuzima fatizo. Nubwo imbwa yaba idafite ibimenyetso bitewe no kwinjira kwuzuye, kumenya imiterere yabyo ituma ba nyirayo bahindura ubuvuzi hamwe nicyemezo cyubuvuzi kugirango birinde imbarutso - kurinda inyamaswa zo mu rugo kwirinda iki kibazo cyangiza ubuzima.

Igihe cyo kohereza: Ugushyingo-13-2025