Amakuru y'amatungo: iterambere mu bushakashatsi bwa Avian

Amakuru 01

Kumenya bwa mbere H4N6 Subtype ya Virusi ya Drewerza muri Mallard Ducks (Anas Platyrychos) muri Isiraheli

Avishai Lublin, Nikki Thie, Irina SHKODA, Umusumari Simanov, Gila Kahila Harnoushi, Roni Umwami, Pauline L RK

PMid: 35687561; Doi: 10.1111 / Tbed.14610

Virusi y'ibicurane (AIV) ibangamira ubuzima bukomeye ku buzima bw'amatungo n'ubumuntu ku isi. Nkuko amaziFiwl transtal transmit aio kwisi yose, iperereza ku buryange bwa AV mu baturage bo mu gasozi ni ngombwa mu gusobanukirwa indwara ya pathogen no guhanura indwara y'indwara mu nyamaswa zo mu rugo n'abantu. Muri ubu bushakashatsi, H4N6 SubType AIV yigunze ku nshuro ya mbere kuva ku ntera ya Fashil y'icyatsi kibisi cy'icyatsi kibisi (Anas Platyrychos) muri Isiraheli. Ibisubizo bya Phylogenetic ibya ha na Na na Na ntabwo byerekana ko iyi mihangayiko ifitanye isano rya bugufi nu Burayi na Aziya isoalates. Nkuko Isiraheli iherereye munzira yo hagati ya Arctique-Afurika, hafatwa ko guhangayikishwa byatangijwe n'inyoni z'abimukira. Isesengura rya Phylogenetoic ya gen (PB2, PB2, P, NP, M na NS) byagaragaje urugero rwibijyanye na AIV subtyner, zivuga ko ibintu byo kwizirika kwabanjirije. Iyi H4N6 Subtype ya AIV ifite igipimo kinini cyo kwizirikana, irashobora kwanduza ingurube nziza no guhambira abashyitsi bakirwa abantu, kandi rishobora gutera indwara Zonotic mugihe kizaza.

Amakuru 02

Incamake ya Avian Trippenza muri EU, Werurwe-2022

Ikigo cy'umutekano cy'ibiryo, Ikigo cy'iburayi cyo gukumira indwara no kugenzura, Laboratwari

PMid: 35949938; PMCID: PMC9356771; DOI: 10.2903 / J.EFSA.20.7415

Muri 2021-2022, Pathogenic Avian Drinepenza (HPAI) niyo yari icyorezo gikomeye cyane mu Burayi, icyorezo cya 2,398 mu bihugu 36 by'Uburayi byaturutse mu nyoni miliyoni 46 zibangamira inyoni miliyoni 46 zibangamira inyoni miliyoni 46 zibangamira inyoni miliyoni 46 zibangamiye. Hagati ya 16 Werurwe na 10 Kamena 2022, ibihugu 28 by'ubwongereza ndetse n'ubwongereza 1 182 byatewe n'indwara z'inkoko (Imanza 750), imanza 410) n'inzego zinyago (22). Muri icyo gihe, 86% by'ibyorezo by'inkoko byatewe no kohereza HPAIV, hamwe n'ubufaransa ku birori by'inkoko rusange, Hongiriya kuri 24% n'ibindi bihugu byagize ingaruka ku munsi wa 2% buri umwe. Ubudage bwari bufite umubare munini w'ibiti mu nyoni zo mu gasozi (imanza 158), hakurikiraho Ubuholandi (imanza 98) n'Ubwongereza (48).

Ibisubizo by'isesengura genetike byerekana ko HPPOIIT ihendutse mu Burayi ahanini ni izamutwe 2.3.4 b. Muri Amerika ndetse na bane H5N6, babiri H9N2 n'indwara zanduye za muntu H3N1. Ibyago byo kwandura byasuzumwe nkabaturage muri rusange no gushyira mu gaciro kubaturage bagaragaza akazi muri EU / Eea.

 Amakuru 03

Guhinduka kw'ibisigi 127, 183 na 212 kuri leta ya ha gene

Kwiga, kwigana no gukundana bya virusi ya H9N2 Avian

Menglu Umufana,Bing Liang,Yongzhen Zhao,YapIng Zhang,Qingzheng Liu,Miao Tian,Yiqing Zheng,Huizhi xia,Yasuo Suzuki,Umukeri wa Hualan,Jihui Ping

PMid: 34724348; Doi: 10.1111 / tbed.14363

H9N2 Subtype ya virusi ya Avian (AIV) nimwe mubyiciro bikomeye bireba ubuzima bwinganda zikositimu. Muri ubu bushakashatsi, imigenzo ibiri ya H9N2 Subtype AIV hamwe ninyuma ya genetique ariko yiswe a / inkoko / 76/2018 (js / 76), yari yitaruye mu isambi y'inkoko. Isesengura rikurikiranye ryerekanaga ko JS / 75 na JS / 76 byari bitandukanye mubisigi bitatu bya Acino (127, 183 na 212) bya Haemaglutinin (Ha). Gushakisha itandukaniro mu buryo bwibinyabuzima hagati ya JS / 75 na JS / 76, virusi esheshatu za recombinant zakoresheje uburyo bwihuse hamwe na / puerto Rico / 8/114 (Pr8) nkinyungu nyamukuru. Amakuru yibasiye inkoko hamwe nibizamini byerekanwe ko R-76 / PR8 yerekanye ibintu byagabanijwe cyane kubera ihinduka rya Amine acide kumyanya 127 na 183 muri Ha gene. Ubundi buryo bwemeje ko Glycosylation ku rubuga rwa 127N yabaye muri JS / 76 na mutants. Kwakira ibishanguye byerekanaga ko virusi zose zinjira, usibye 127n Glycosylation-idafite ubudahinnye, byimazeyo kubakira. Gukura Kinetics hamwe nigitero cyimbeba zamagana byerekana ko virusi ya 127N-glycosylate yigana munsi ya selile ya a549 kandi yari ipaji cyane kandi yari inyangamugayo mu mbeba ugereranije na virusi yishyamba. Rero, Glycosylation na Amino aside acino muri gene bashinzwe itandukaniro riri mu burere no gukunda igihugu cya 2 H9N2.

Inkomoko: Ubushinwa Ubuzima nububiko bwibigo