Amakuru yubuvuzi bwamatungo: Iterambere mubushakashatsi bwibicurane by'ibiguruka

Amakuru 01

Kumenya bwa mbere ubwoko bwa H4N6 bwa virusi yibicurane by'ibiguruka mu njangwe za mallard (Anas platyrhynchos) muri Isiraheli

Avishai Lublin ， Nikki Thie ， Irina Shkoda ， Luba Simanov ， Gila Kahila Bar-Gal ， Yigal Farnoushi ， Roni King ， Wayne M Getz ， Pauline L Kamath ， Rauri CK Bowie ， Ran Nathan

PMID ： 35687561 ； DOI ： 10.1111 / tbed.14610

Virusi y'ibicurane by'ibiguruka (AIV) ibangamiye cyane ubuzima bw'inyamaswa ndetse n'abantu ku isi. Nkuko inyoni zo mu gasozi zanduza AIV ku isi hose, gukora ubushakashatsi ku bwiyongere bwa AIV mu baturage bo mu gasozi ni ingenzi mu gusobanukirwa kwanduza indwara no guhanura indwara z’inyamaswa zo mu rugo ndetse n’abantu. Muri ubu bushakashatsi, ubwoko bwa H4N6 bwitwa AIV bwatandukanijwe bwa mbere n’icyitegererezo cy’ibisimba by’ibisimba byo mu gasozi (Anas platyrhynchos) muri Isiraheli. ibisubizo bya phylogeneque ya gen na HA na NA byerekana ko iyi miterere ifitanye isano rya bugufi n’ibihugu by’i Burayi na Aziya. Kubera ko Isiraheli iherereye mu majyepfo ya Arctique-Afurika yimuka, hafatwa ko iyo miterere ishobora kuba yarazanywe n’inyoni zimuka. Isesengura rya phylogeneque ryerekeye ingirabuzimafatizo zo mu bwigunge (PB1, PB2, PA, NP, M na NS) ryagaragaje urwego rwo hejuru rwa phylogeneque rufitanye isano n’ubundi bwoko bwa AIV, byerekana ko ikintu cyabanjirije kwiyubaka cyabereye muri ubu bwigunge. Ubu bwoko bwa H4N6 bwa AIV bufite umuvuduko mwinshi wo kwiyubaka, burashobora kwanduza ingurube nzima no guhuza abantu, kandi birashobora gutera indwara zoonotic mugihe kizaza.

Amakuru 02

Incamake y'ibicurane by'ibiguruka muri EU, Werurwe-Kamena 2022

Ikigo gishinzwe umutekano w’ibiribwa Center Ikigo cy’i Burayi gishinzwe gukumira no kurwanya indwara ratory Laboratoire y’ubumwe bw’ibihugu by’i Burayi ishinzwe ibicurane by’ibiguruka

PMID ： 35949938 ； PMCID ： PMC9356771 ； DOI ： 10.2903 / j.efsa.2022.7415

Mu 2021-2022, ibicurane by’ibiguruka byanduye cyane (HPAI) nicyo cyorezo gikomeye cyane mu Burayi, aho icyorezo cy’ibiguruka 2,398 mu bihugu 36 by’Uburayi bituma inyoni miliyoni 46 zicwa. hagati ya 16 Werurwe na 10 Kamena 2022, ibihugu 28 byose by’ubumwe bw’ibihugu by’Uburayi / EEA n’Ubwongereza 1 182 by’ibicurane by’ibicurane by’ibiguruka byanduye cyane (HPAIV) bitandukanijwe n’inkoko (abantu 750), inyamaswa zo mu gasozi (410) n’inyoni zafashwe (22) manza). Mu gihe kirimo gusubirwamo, 86% by’ibiguruka by’inkoko byatewe no kwandura HPAIV, aho Ubufaransa bungana na 68% by’ibyorezo by’inkoko muri rusange, Hongiriya 24% n’ibindi bihugu byibasiwe na munsi ya 2% buri umwe. Ubudage nabwo bwanduye cyane mu nyoni zo mu gasozi (158), bukurikirwa n'Ubuholandi (98) n'Ubwongereza (48).

Ibisubizo by'isesengura rishingiye ku ngirabuzima fatizo byerekana ko HPAIV yanduye mu Burayi ahanini ni iy'ibice 2.3.4 b. Kuva raporo iheruka, mu Bushinwa hagaragaye H5N6 enye, H9N2 ebyiri na H3N8 ebyiri zanduye abantu kandi muri Amerika haravugwa ubwandu bwa H5N1. Ibyago byo kwandura byagaragaye ko ari bike ku baturage muri rusange ndetse no ku rugero ruto ku rugero rw’abaturage bagaragara ku kazi muri EU / EEA.

 Amakuru 03

Guhinduka kw'ibisigisigi 127, 183 na 212 kuri gene ya HA bigira ingaruka

Antigenicity, kwigana no gutera virusi ya H9N2 virusi yibicurane

Umufana wa Menglu，Bing Liang，Yongzhen Zhao，Yaping Zhang，Qingzheng Liu，Miao Tian，Yiqing Zheng，Huizhi Xia，Yasuo Suzuki，Hualan Chen，Jihui Ping

PMID ： 34724348 ； DOI ： 10.1111 / tbed.14363

Ubwoko bwa H9N2 bwa virusi yibicurane by'ibiguruka (AIV) ni bumwe mu bwoko bukomeye bugira ingaruka ku buzima bw'inganda z’inkoko. Muri ubu bushakashatsi, amoko abiri ya H9N2 subtype AIV afite ubwoko busa ariko antigenicite itandukanye, yitwa A / inkoko / Jiangsu / 75/2018 (JS / 75) na A / inkoko / Jiangsu / 76/2018 (JS / 76), kwitandukanya n'ubworozi bw'inkoko. Isesengura ryikurikiranya ryerekanye ko JS / 75 na JS / 76 bitandukanye mu bisigazwa bitatu bya aside amine (127, 183 na 212) bya haemagglutinin (HA). Kugirango hamenyekane itandukaniro ryimiterere yibinyabuzima hagati ya JS / 75 na JS / 76, virusi esheshatu za recombinant zakozwe hakoreshejwe uburyo bwa genoside butandukanye hamwe na A / Porto Rico / 8/1934 (PR8) nkumunyururu nyamukuru. Imibare yavuye mu bizamini byibasiye inkoko hamwe n’ibizamini bya HI yerekanaga ko r-76 / PR8 yerekanye guhunga antigenic byagaragaye cyane kubera ihinduka ry’imiterere ya aside amine ku mwanya wa 127 na 183 muri gene ya HA. Ubundi bushakashatsi bwemeje ko glycosylation kuri site ya 127N yabereye muri JS / 76 hamwe na mutant. Receptor binding assays yerekanye ko virusi zose zongera kwiyongera, usibye 127N ya glycosylation-yabuze mutant, byoroshye guhita byakira abantu. Iterambere rya kinetics hamwe nimbeba yibitero byerekanaga ko virusi ya 127N-glycosylated yanduye gake muri selile A549 kandi ko itigeze itera indwara yimbeba ugereranije na virusi yo mubwoko. Rero, glycosylation hamwe na aside amine ihindagurika muri gene ya HA ishinzwe itandukaniro rya antigenicite na patogeneicite ya 2 H9N2.

Inkomoko: Ikigo cy’Ubuzima bw’Ubuzima n’Icyorezo cya Epidemiologiya