Uburozi bwa Omiron bwaragabanutse bangahe? Ubushakashatsi bwinshi-bwisi bugaragaza

"Virsulence ya Omirnce yegereye ibicurane by'imikino" na "Omirron birakabije cyane pathogenic kuruta delta". ...... Vuba

Mubyukuri, kuva hagaragaye Omirron Mutant Strain mu Gushyingo 2021 hamwe nuburwayi bwayo ku isi, ubushakashatsi n'ibiganiro kuri viruulence no kwanduza byakomeje. Nubuhe buryo bwo kuringaniza? Ubushakashatsi buvuga iki kuri bwo?

Inyigisho za Laboratoire zitandukanye: Omicron ntabwo ari virulent
Mubyukuri, nko mu ntangiriro ya 2022, ubushakashatsi bwatanzwe na kaminuza ya Hong Kong Li Ka Shing Ishami ry'imiti yasanze Omirron (B.1.1,529) irashobora kuba inyangamugayo n'ibindi musant.
Byasanze ko Omirron Mutant Stice idakora neza mu gukoresha Erine Protesee Protease (tmprss2), mugihe tmprss2 yashoboraga koroshya igitero cya virusi mukwoza poroteyine ya coronabiru nshya. Muri icyo gihe, abashakashatsi bagaragaje ko kwigana omirron byagabanutse cyane mu murongo wa selile muntu Calu3 na Caco2.

Ishusho Inkomoko ya interineti

Muri K18-Hace2 imbeba yimbeba, kwigana kwa Omicron byagabanutse mumitsi yo hejuru no hepfo yimbeba ugereranije na Delta yateje uburemere no gupfa, mugihe cyanduye cya Delta cyateje uburemere bukabije ndetse nurupfu rwa Alpha, Beta, Beta na Delta.
Kubwibyo, abashakashatsi banzuye ko kwigana no kwigana no gukundana byagabanutse mu rubibe.

Ishusho Inkomoko ya interineti

Ku ya 16 Gicurasi 2022, kamere yasohoye impapuro ya Yoshihiro Kawuka, iyobowe na virologo ya Tokiyo na kaminuza ya Wisconsin, yemeza bwa mbere mu cyitegererezo cy'inyamaswa OMIRON BA.

Abashakashatsi batoranijwe muri Virusi ya Bashya Batandukira K18-Hace2 imbeba na Hamsters basanga, bombi b'indorerezi zanduye zari zaranduye ku mazu y'ikamba (p <0.0001).

Igisubizo gisanzwe cya zahabu cyemeza ko Omirron rwose ari virubile kuruta ubwoko bwishyamba bwumwimerere. Ibinyuranye, nta tandukaniro rikomeye mu gitabo cyanditse mu bihaha n'amazuru y'ingendo z'inyamaswa zikurikira Ba.2 na Ba.1.

Ishusho Inkomoko ya interineti

PCR virusi yishyuye yerekana ko bombi bar Ba.2 na Ba.1 imbeba zanduye zifite virusi zo hasi mu bihaha no mu mazure kuruta ibihaha bishya, cyane cyane mu bihaha (p <0.0001).

Bisa n'ibisubizo mu mbeba, igitabo cya virusi cyagaragaye mu zuru n'ibihaha bya bal yanduye byari munsi yurubanza rwabambere kuruta Ba.1 - Mubyukuri, kimwe cya kabiri cya Ba.2 zanduye rwanduye.

Byaragaragaye ko imihangayiko y'umwimerere, Ba......

Ishusho Inkomoko ya interineti

Amakuru Yisi Yukuri: Omicron ntigishobora gutera indwara ikomeye

Benshi mu bushakashatsi bwavuzwe haruguru basobanuye virusi yagabanijwe na omicron muri traboratoire yinyamanswa, ariko ni ko bimeze no ku isi.

Ku ya 7 Kamena 2022, wasohoye raporo isuzuma itandukaniro muburemere bwabantu banduye mugihe omidic ugereranije na pandemic ya Delta.

Raporo irimo 16.749 abarwanyi bashya b'imiryango baturutse mu ntara zose zo muri Afurika y'Epfo, barimo 16.749 uhereye ku cyaha (2021/8/200/3,693 mu cyorezo cya Omidron (2021/11/16 kugeza 20222). Abarwayi na bo bashyizwe mu bihe bikomeye, bikomeye kandi bidakomeye.

Kunegura: Umaze kubona umuyaga uhumeka, cyangwa ogisijeni no hejuru ya ogisijeni ndende, cyangwa ogisijeni ndende (ECMOPORenal Megyenial (ECMO), cyangwa kwinjira muri ICU mu bitaro.
-Erekana (gukabije): yakiriye ogisijeni mugihe cyo gutambirwa
-non-gukomera: Niba ntanumwe muribi wavuzwe haruguru bwujujwe, umurwayi ntabwo akomeye.

Amakuru yerekanaga ko mu itsinda rya Delta, 49.2% bari bakomeye, 7.7% bari bakomeye kandi bagera kuri 28% banduye DEMTA, 31% bari banduye, 3.1% bari barwaye ibitaro byanduye. Kandi, uburebure bwo hagati bwo guma bwari iminsi 7 mumatsinda ya Delta ugereranije n'iminsi 6 mumatsinda ya Omirron.

Byongeye kandi, raporo yasesenguye inzira y'imyaka, uburinganire, urukingo n'imiterere y'imikondo maze binjira mu burwayi bwo hasi (95%.

Ishusho Inkomoko ya interineti

Kuri subtypes zitandukanye, ormiron, andi masomo nayo yasesenguye virusi muburyo burambuye.

Kwiga Cohort kuva mu Bwongereza bushya bwasesenguye imanza 20770 za Delta, 52605 imanza za OMIRON B.1.1.529 na 29840 kuri Delta, 0,4% kuri B.1.1.3% na 0.3% kuri Ba.2. Nyuma yo guhindura ibintu bigize, ubushakashatsi bwanzuye ko ibyago byo gupfa byari bike kuri Ba.2 ugereranije na Delta na B.1.1..1.529.

Ishusho Inkomoko ya interineti

Ubundi bushakashatsi bwaturutse muri Afurika y'Epfo bwasuzumye ibyago byo gushyirwa mu bitaro n'ibyago byo ku byavuye muri Delta, Ba.1 na Ba.2 / Ba.5. Ibisubizo byerekanaga ko abarwayi 98.710 banduye bakubiswe mu bitaro, muri bo 1276 (33.4%) bateye indwara zikomeye.

Mu banduye ihinduka ritandukanye, 57.7% by'abarwayi banduye delta batojwe indwara zikomeye (97.68), ugereranije na 33.7% ya Ba.1. Isesengura ryinshi ryerekanye ko amahirwe yo guteza imbere indwara ikomeye muri Delta yanduye> Ba.1> Ba.2, nubwo amahirwe yo guteza imbere indwara ikomeye mu banduye banduye Ba.2.
Yagabanije virusi, ariko kuba maso birakenewe

Ubushakashatsi bwa laboratoire hamwe namakuru nyawo baturutse mubihugu byinshi bagaragaje ko Omirron na subtypes bayo badafite ubururu bukabije kandi ntibakunze gutera indwara ikomeye kuruta izindi musan.

Icyakora, hasubirwamo ingingo yo nomero ya 2022 yo mu nomero ya Lancet, yiswe 'Loer ariko ntabwo yitonda', igipimo cyo kwandura. .

Mu gusoza raporo yavuzwe haruguru, iyi tsinda yavuze ko nubwo yagabanije virusi zabanje, hafi kimwe cya gatatu cya Omintwari. . gutanga umusanzu mubintu bikomeye no gupfa.)

Amakuru yabanjirije kuva Omirron igihe yazamuraga umuvuduko wa gatanu wacyo icyorezo muri Hong Kong yavuze ko guhera ku ya 4 Gicurasi 2092765, hapfuye abantu bapfa.

Ibinyuranye, 2% gusa bya Nouvelands nshya hejuru yimyaka 60 ntibakunze, bifitanye isano cyane nimpfumu nke za mugitondo cya 0.07% kubwikicyo cyorezo cya Crodip.

Ku rundi ruhande, mu gihe harakunze gutandukanwa ko Newcastle ishobora kuba indwara y'ibihe, ifite ubwoba mu gihe kizaza, hari impuguke mu masomo bafata ukundi.

Abahanga batatu bo muri kaminuza ya Oxford hamwe n'ikigo cy'ubushakashatsi bw'ibihugu by'Uburayi bizera ko uburemere bwo hasi bwa Omirvon bushobora kuba impanuro, kandi byakomeje ubwihindurize (ubwo bwihindurize bwa antigenic) bushobora kuzana impinduka nshya.

Mu buryo butandukanye no guhunga no kwanduzwa, bigengwa nigitutu gikomeye, virurungano mubisanzwe 'ibicuruzwa' byubwihindurize. Virusi irahinduka kugirango ibaze ubushobozi bwabo bwo gukwirakwira, kandi ibi birashobora kandi gutera kwiyongera muri viruhence. Kurugero, mu kongera imitwaro ya virusi kugirango yorohereze kohereza, irashobora gutuma indwara zikomeye.

Ntabwo aribyo gusa, ahubwo ko viruru nabyo bizatera ibyago bike mugihe cyakwirakwijwe na virusi, nkuko bigaragara kuri virusi, virusi itera SIDA, kugira umwanya muto wo gukwirakwira mbere.

Ishusho Inkomoko ya interineti

Mu bihe nk'ibi, birashobora kugorana guhanura inzira ya karkunt ya musan ya Mutant yo muri Omirning, ariko inkuru nziza ni uko umubare munini wimyambarire yagabanutseho indwara ya mutant yose, kandi igikomere gikomeza kwiyongera ku miterere yose ya mutant.
Gushimira: Iyi ngingo yasuzumwe iteganwe na Panaman Zhou, PhD, Tsinghua Ishuri rya kaminuza rya kaminuza na Postdoctictol, Ikigo cy'ubushakashatsi bw'umwanditsi, Amerika
Ominron kwipimisha antigen mu rugo