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Imbwa zimwe zifata imiti igabanya ubukana nta kibazo, mugihe izindi zikurakuruka no gucibwamo. Urashobora guha imbwa yawe imiti igabanya ububabare ukurikije uburemere bwayo, nyamara nta ngaruka igira cyangwa igasiga amatungo yawe ubunebwe. - Ibi birashoboka cyane ko bifitanye isano nagene irwanya gene (MDR1)mu mubiri w'imbwa.
Iyi "igenzura itagaragara" ya metabolism yibiyobyabwenge ifite urufunguzo rwumutekano wimiti kubitungwa, kandiKwipimisha aside nucleic ya MDR1nuburyo bwingenzi bwo gufungura iyi code.
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Urufunguzo rwumutekano wimiti: MDR1 Gene
Kugira ngo twumve akamaro ka gene MDR1, tugomba mbere na mbere kumenya “akazi kayo” - gukora nk'umukozi ushinzwe gutwara abantu n'ibintu. Gene MDR1 iyobora synthesis yibintu byitwa P-glycoprotein, bikwirakwizwa cyane hejuru yutugingo ngengabuzima mu mara, umwijima, nimpyiko. Irakora nka sitasiyo yabugenewe yo gutwara ibiyobyabwenge:
Imbwa imaze gufata imiti, P-glycoprotein isohora imiti irenze ingirabuzimafatizo ikayirukana binyuze mu mwanda cyangwa inkari, ikarinda kwirundanya kwangiza mu mubiri. Irinda kandi ingingo zingenzi nkubwonko nigufwa ryamagufwa birinda ibiyobyabwenge byinjira cyane bishobora kwangiza.
Ariko, niba gene MDR1 ihindagurika, uyu "mukozi ushinzwe gutwara abantu" atangira gukora nabi. Irashobora guhinduka cyane, gusohora imiti vuba vuba kandi bigatera amaraso adahagije, bikagabanya cyane ibiyobyabwenge. Cyangwa irashobora kuba yarabangamiye imikorere, ikananirwa gukuraho ibiyobyabwenge mugihe, bigatuma imiti yegeranya kandi igatera ingaruka nko kuruka cyangwa umwijima nimpyiko.- Iyi niyo mpamvu imbwa zishobora kwitabira bitandukanye kumiti imwe.
Ndetse birenzehoni uko MDR1 idasanzwe ikora nka "mines" zihishe - mubisanzwe bitamenyekana kugeza imiti itera ibyago. Kurugero, imbwa zimwe zavutse zifite genes za MDR1 zifite inenge, kandi dosiye isanzwe yimiti igabanya ubukana (nka ivermectin) irashobora gutera ataxia cyangwa koma iyo itanzwe akiri muto. Izindi mbwa zifite imikorere idakabije ya MDR1 zirashobora kugabanya ububabare bubi bwa opioide nubwo zifatwa neza nuburemere. Ibi bibazo ntabwo biterwa n "imiti mibi" cyangwa "imbwa zidakorana," ahubwo ni ingaruka za genetique.
Mubikorwa byubuvuzi, amatungo menshi agira ikibazo cyimpyiko zikabije cyangwa kwangirika kwimitsi nyuma yo gufata imiti atabanje kwisuzumisha MDR1 - ntabwo biganisha kumafaranga menshi yo kuvura ahubwo binababaza inyamaswa bidakenewe.
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Kwipimisha genetike kugirango wirinde ingaruka ziterwa n'imiti
Kwipimisha Canine MDR1 gene nucleic acide nurufunguzo rwo gusobanukirwa "akazi kakazi" k'abatwara hakiri kare. Bitandukanye no gukurikirana amaraso gakondo - bisaba kuvoma amaraso nyuma yo gufata imiti - ubu buryo burasesengura mu buryo butaziguye gene MDR1 yimbwa kugirango hamenyekane niba ihinduka ryimiterere nubwoko bwabyo.
Logic iroroshye kandi isa na hyperthermia malignant test genetique, igizwe nintambwe eshatu zingenzi:
1. Icyegeranyo cy'icyitegererezo:
Kuberako gene MDR1 ibaho muri selile zose, harakenewe gusa urugero ruto rwamaraso cyangwa swab yo mu kanwa.
2. Gukuramo ADN:
Laboratoire ikoresha reagent idasanzwe kugirango itandukanya ADN yimbwa kurugero, ikuraho poroteyine nindi myanda kugirango ibone icyitegererezo cyiza.
3. Kwiyongera kwa PCR no gusesengura:
Ukoresheje iperereza ryihariye ryagenewe imbuga za MDR1 zingenzi (nka canine nt230 [del4] ihinduka), PCR yongerera intego gen. Igikoresho noneho kimenya ibimenyetso bya fluorescent kuva kuri probe kugirango hamenyekane ihinduka ryimiterere ningaruka zikorwa.
Inzira yose ifata amasaha agera kuri 1-3. Ibisubizo bitanga ubuyobozi butaziguye kubaveterineri, bituma bahitamo imiti itekanye kandi yuzuye kuruta kwishingikiriza kubigeragezo-no-kwibeshya.
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Itandukaniro rishingiye ku ngirabuzima fatizo, Umutekano wabonye imiti
Abafite amatungo barashobora kwibaza: MDR1 idasanzwe ivuka cyangwa yarayibonye?
Hariho ibintu bibiri by'ingenzi, hamwe na genetique niyo yambere:
Ubwoko-Imiterere yihariye ya genetike
Iyi niyo mpamvu ikunze kugaragara. Igipimo cya mutation kiratandukanye cyane kubwoko:
- Amashanyarazi.
- Abashumba ba AustraliyanaIntama za kera zicyongerezakandi werekane ibiciro biri hejuru.
- Ubwoko nkaChihuahuasnaPoodlesugereranije igipimo gito cya mutation.
Ibi bivuze ko niyo imbwa itigeze ifata imiti, ubwoko bwibyago byinshi birashobora gutwara mutation.
Imiti n'ingaruka ku bidukikije
Mugihe gene MDR1 ubwayo ivuka, gukoresha igihe kirekire cyangwa gukoresha ibiyobyabwenge bimwe na bimwe birashobora "gukora" imvugo idasanzwe.
Gukoresha igihe kirekireantibiyotike(urugero, tetracyclines) cyangwaimmunosuppressantsirashobora gutera indishyi zirenze urugero za MDR1, bigana imiti irwanya ibiyobyabwenge nubwo nta mutation ihari.
Imiti imwe n'imwe yangiza ibidukikije (nk'inyongeramusaruro y'ibikomoka ku matungo make) nayo ishobora kugira ingaruka ku buryo butaziguye gene ihagaze.
Gene MDR1 yibasira imiti myinshi, harimo imiti igabanya ubukana, imiti igabanya ububabare, antibiotike, imiti ya chimiotherapie, n'imiti igabanya ubukana. Urugero:
Collie itwaye inenge irashobora kugira neurotoxicity ikabije ndetse no kuri ivermectine.
Imbwa zifite MDR1 zirenze urugero zishobora gusaba ibipimo byahinduwe byimiti igabanya ubukana bwindwara zuruhu kugirango bigerweho neza.
Niyo mpamvu abaveterineri bashimangira cyane gusuzuma MDR1 mbere yo kwandikira amoko afite ibyago byinshi.
Kubafite amatungo, gupima aside nucleic ya MDR1 itanga uburinzi bubiri kumutekano wimiti:
Gupima ubwoko bwibyago byinshi hakiri kare (urugero, Collies) byerekana imiti yica ubuzima bwawe bwose kandi ikarinda uburozi butunguranye.
Imbwa zisaba imiti yigihe kirekire (nko kubabara karande cyangwa igicuri) irashobora kugira ibipimo byahinduwe neza.
Kugerageza gutabara cyangwa imbwa zivanze-bikuraho ibintu bidashidikanywaho kubyerekeye ingaruka zishingiye ku ngirabuzima fatizo.
Ifite agaciro cyane cyane imbwa nkuru cyangwa abafite uburwayi budakira, bakeneye imiti kenshi.
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Kumenya imbere bivuze kurinda neza
Ukurikije ibisubizo by'ibizamini, dore ibyifuzo bitatu byo kwirinda imiti:
Ubwoko bwibyago byinshi bigomba gushyira imbere kwipimisha.
Collies, Abashumba bo muri Ositaraliya, nubwoko busa bigomba kurangiza MDR1 mbere y amezi 3 yubuto kandi bigakomeza ibisubizo kuri dosiye hamwe nubuvuzi bwamatungo.
Buri gihe ujye ubaza umuganga wawe ibijyanye na "genetique ihuza" mbere yo gutanga imiti.
Ibi nibyingenzi kumiti ishobora guhura ninshi nkimiti igabanya ubukana hamwe nubuvuzi bubabaza. Nubwo ubwoko bwimbwa yawe butagira ibyago byinshi, amateka yimyitwarire mibi bivuze ko hakwiye gusuzumwa geneti.
Irinde kwivuza ukoresheje imiti myinshi.
Imiti itandukanye irashobora guhatanira imiyoboro yo gutwara P-glycoprotein. Ndetse genes zisanzwe za MDR1 zirashobora kurengerwa, biganisha ku busumbane bwa metabolike kandi byongera ingaruka zuburozi.
Akaga ko guhinduka kwa MDR1 kari mu kutagaragara - kwihishe mu buryo bukurikirana, nta kimenyetso cyerekana kugeza imiti itunguranye.
Kwipimisha aside MDR1 nucleic ikora nka disiketi ya minisiteri isobanutse neza, idufasha gusobanukirwa nimbwa ya metabolism yibiyobyabwenge mbere yimbwa. Mu kwiga uburyo bwayo nuburyo bwo kuzungura, gukora ibizamini hakiri kare, no gukoresha imiti neza, dushobora kwemeza ko mugihe amatungo yacu akeneye kuvurwa, bahabwa ubufasha bwiza mugihe birinda ingaruka zimiti - kurinda ubuzima bwabo muburyo bufite inshingano.
Igihe cyo kohereza: Ugushyingo-20-2025
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